NF-κB1 Is Required for Optimal CD4+Th1 Cell Development and Resistance toLeishmania major
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NF- B1 Is Required for Optimal CD4 Th1 Cell Development and Resistance to Leishmania major
The NFB family of transcription factors regulates the expression of a wide range of immune response genes involved in immunity to pathogens. However, the need for individual family members in regulating innate and adaptive immune responses in vivo has yet to be clearly defined. We investigated the role of NFB1 in the induction of protective IL-12-dependent Th1 cell responses following infection...
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*INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, F-31300, France; † INSERM, U858, Institut de Médecine Moléculaire de Rangueil, Toulouse, France; ‡ Université Paul Sabatier, Toulouse, F-31400 France; § Centre Hospitalier Universitaire, Toulouse, France; ¶ CNRS, UMR6101, Faculté de Médecine, Limoges, F-87025 France; ll IGBMC, CNRS-INSERM-ULP-Collège de France, Illkirch, F-...
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The importance of IκB kinase (IKK)-induced proteolysis of NF-κB1 p105 in B cells was investigated using Nfkb1(SSAA/SSAA) mice, in which this NF-κB signaling pathway is blocked. Nfkb1(SSAA) mutation had no effect on the development and homeostasis of follicular mature (FM) B cells. However, analysis of mixed bone marrow chimeras revealed that Nfkb1(SSAA/SSAA) FM B cells were completely unable to...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2003
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.170.4.1995